Welcome to the Laboratory for Computational Systems Biology at the Freiburg Institute for Advanced Studies (FRIAS).
Research
We investigate how disease and other perturbations critically affect normal network structures of interactions between DNA, RNA, proteins and metabolites, and how the dynamics of perturbed networks explains biological functioning at a system level. Our lab specializes in the development of methods, algorithms and software for the integration, analysis and modeling of high-throughput, genome-wide data. We collaborate with experimental life science groups to obtain data and interpret and validate results.
Module networks revisited: computational assessment and prioritization of model predictions, Bioinformatics 25, 490 - 496 (2009).
(A. Joshi, R. De Smet, K. Marchal, Y. Van de Peer, T. Michoel) [journal][PDF]
RNA regulon-omics - A portal for molecular biologists who wish to design detailed hypotheses from a large-scale, top-down analysis of posttranscriptional regulation in yeast. [homepage][paper]
Network Motif Clustering Toolbox - a Matlab toolbox for clustering topological motifs in integrated networks. [homepage][paper]
